The U.S. cannabis market has evolved into a sophisticated industry where a handful of companies dominate distribution, wholesale, and multi-state retail operations. These top marijuana distribution companies play a crucial role in connecting cultivators, processors, and retailers while ensuring products meet the highest standards for safety, compliance, and customer satisfaction.
Curaleaf Holdings Inc.
Founded in 2010 (formerly PalliaTech), Curaleaf is the world’s largest cannabis company by revenue. It operates in 19 U.S. states with over 140 retail locations. Known for acquisitions like Select, Grassroots, and BlueKudu, Curaleaf offers diverse products: flowers, oils, edibles, topicals.
Website: curaleaf.com
Trulieve Cannabis Corp.
Based in Florida (est. 2013), Trulieve generated $1.2 B+ in revenue (2022), becoming the largest U.S. cannabis company at one point. With 200+ stores and a strong presence in Florida and expanding in Ohio, Trulieve emphasizes vertical integration, high margins, and customer loyalty.
Website: trulieve.com
Green Thumb Industries (GTI)
Founded in 2014 and headquartered in Chicago, GTI operates 100+ dispensaries and 20 manufacturing facilities across 15 U.S. states. Its well-known brands include RYTHM, incredibles, Beboe, and Dogwalkers, with a reputation for strong branding and social responsibility.
Website: gtigrows.com
Cresco Labs
Chicago-based Cresco Labs (founded 2013) operates Sunnyside dispensaries in nine states and has 3,000+ employees. With 2024 revenue hitting $1 B, Cresco’s brands—Cresco, High Supply, Reserve—enjoy high consumer ratings. It’s known for its wellness-focused branding and strategic acquisitions like Origin House and VidaCann.
Website: crescolabs.com
Verano Holdings
A vertically integrated MSO operating in 14 states, including flagship markets like Illinois, Florida, and Pennsylvania. 2023 revenue reached ~$982 M. Its premium brands—Verano, Avexia, Encore—are widely sold in both medical and adult-use markets.
Website: verano.com
TerrAscend
This MSO has operations in Michigan, Pennsylvania, Maryland, and others, with ~20 dispensaries and 7 cultivation sites. 2023 revenue was approximately $350 M. TerrAscend emphasizes sustainable cultivation and clean-label products such as edibles and concentrates.
Website: terrascend.com
Ayr Wellness
Operating in 10 states with 50+ retail locations, Ayr Wellness generated $586 M in 2023. Known for high-quality flower, edibles, concentrates, and strategic acquisitions, Ayr targets large-scale cultivation and retail growth.
Website: ayrwellness.com
Innovative Industrial Properties (IIP)
The first cannabis-focused REIT (real estate investment trust) listed on NYSE. IIP owns and leases cultivation/retail facilities in Ohio, Maryland, New York, Massachusetts, Virginia, and more. It offers a sale-leaseback model, providing essential capital infrastructure to licensed operators.
Website: iiprop.com
Planet 13 Holdings
Nevada-based, Planet 13 operates the world’s largest cannabis superstore in Las Vegas (112,000 sq ft) plus locations in California, Florida, and Illinois. Known for entertainment-driven shopping experiences, its brands include Medizin, Trendi, Leaf & Vine, PURC, and Planet M.
Website: planet13.com
Nabis
A licensed cannabis wholesale and distribution platform serving over 400 licensed dispensaries nationwide. Nabis aggregates top brands and streamlines supply via tech-driven logistics—becoming the go-to wholesale marketplace for dispensaries.
Website: nabis.com